Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898052 | 0.84 | KMT2A (0.46) | ALDH1A1KMT2ANLRP3CA1CA2 | |
| SCHEMBL13857860 | 0.81 | PPARG (0.50) | EPHX2KMT2APPARGAKR1B1MEN1 | |
| SCHEMBL6224100 | 0.80 | NLRP3 (0.46) | KMT2ANLRP3CA1CA2CA12 | |
| SCHEMBL22112689 | 0.80 | NLRP3 (0.46) | KMT2ANLRP3CA1CA2CA12 | |
| SCHEMBL2502292 | 0.79 | NLRP3 (0.45) | ALDH1A1KMT2ANLRP3AKR1B1TSHR | |
| SCHEMBL22113081 | 0.79 | NLRP3 (0.45) | ALDH1A1KMT2ANLRP3AKR1B1TSHR | |
| SCHEMBL2586006 | 0.79 | NLRP3 (0.45) | ALDH1A1KMT2ANLRP3AKR1B1TSHR | |
| SCHEMBL29478100 | 0.79 | NLRP3 (0.45) | ALDH1A1KMT2ANLRP3AKR1B1TSHR | |
| SCHEMBL27420544 | 0.79 | NLRP3 (0.45) | KMT2ANLRP3CA1CA2CA12 | |
| SCHEMBL117431 | 0.78 | CYP1A2 (0.60) | ALDH1A1EPHX2KMT2APPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629372-B2 | Compounds for the treatment of dyslipidemia and other lipid disorders | MERCK & CO., INC. (US) | 2009-12-08 | — | — | US | disclosed |
| US-20080039514-A1 | Compounds for the Treatment of Dyslipidemia and Other Lipid Disorders | MERCK & CO., INC. (US) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039514-A1 | Compounds for the Treatment of Dyslipidemia and Other Lipid Disorders | LIPA, APOB, LCAT | ALDH1A1 660/4885EPHX2 1537/4885KMT2A 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.