Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095076 | 0.81 | CES2 (0.35) | MEN1KMT2ACES2CES1MAOA | |
| SCHEMBL19624772 | 0.80 | AKT1 (0.39) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL14754452 | 0.78 | TSHR (0.43) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL14035651 | 0.76 | NPC1 (0.39) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL9033080 | 0.72 | MEN1 (0.45) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL9033086 | 0.72 | MEN1 (0.45) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL19243907 | 0.70 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL22590936 | 0.69 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1CES2CES1 | |
| SCHEMBL21792057 | 0.68 | LMNA (0.36) | MEN1KMT2AALDH1A1MAOAMAOB | |
| SCHEMBL9421109 | 0.67 | CES2 (0.41) | ALDH1A1CES2CES1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349841-B1 | ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-12-02 | — | — | EP | disclosed |