Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 5/20 | 0.74 |
| ▸ | SNCA | P37840 | 6/20 | 0.57 |
| ▸ | TERT | O14746 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 2/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28307210 | 0.93 | TOP1 (0.62) | TOP1SNCATERTALOX15TOP2A | |
| SCHEMBL29429233 | 0.88 | TOP1 (0.89) | TOP1SNCATERTALOX15HDAC6 | |
| SCHEMBL109009 | 0.88 | TOP1 (0.89) | TOP1SNCATERTALOX15HDAC6 | |
| SCHEMBL11192829 | 0.84 | NPC1 (0.64) | TOP1ALOX15MAPTMEN1KMT2A | |
| SCHEMBL11191641 | 0.84 | NPC1 (0.57) | TOP1ALOX15MAPTMEN1KMT2A | |
| SCHEMBL11192743 | 0.84 | TRPV1 (0.53) | TOP1SNCAALOX15TOP2ATOP2B | |
| SCHEMBL11193981 | 0.84 | TP53 (0.63) | TOP1MAPTMEN1KMT2APKM | |
| SCHEMBL11196144 | 0.84 | SNCA (0.63) | SNCAMEN1KMT2APOLBTDP1 | |
| SCHEMBL11202607 | 0.83 | KMT2A (0.62) | ALOX15MAPTMEN1KMT2APKM | |
| SCHEMBL9009169 | 0.83 | TOP1 (0.62) | TOP1SNCATERTALOX15TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751097-B1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH INC (US) | 2009-12-30 | — | — | EP | disclosed |