Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 5/20 | 0.89 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.66 |
| ▸ | SNCA | P37840 | 6/20 | 0.65 |
| ▸ | TERT | O14746 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | TOP2A | P11388 | 2/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109009 | 1.00 | TOP1 (0.89) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL13593263 | 0.88 | TOP1 (0.74) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL12937374 | 0.88 | TOP1 (0.74) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL11166112 | 0.87 | TOP1 (0.86) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL12706788 | 0.86 | TOP1 (0.72) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL13973596 | 0.85 | TOP1 (0.66) | TOP1ALOX15SNCATERTTOP2A | |
| SCHEMBL7426457 | 0.85 | TOP1 (0.82) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL11793228 | 0.85 | KMT2A (0.73) | TOP1ALOX15MAPTPKMKMT2A | |
| SCHEMBL16317659 | 0.84 | TOP1 (0.64) | TOP1ALOX15SNCATERTHDAC6 | |
| SCHEMBL16350675 | 0.84 | TOP1 (0.64) | TOP1ALOX15SNCATERTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12268669-B2 | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent | PFIZER INC. (US) | 2025-04-08 | — | — | US | disclosed |
| US-20220184041-A1 | (AZA)Benzothiazolyl Substituted Pyrazole Compounds | PFIZER INC. (US) | 2022-06-16 | — | — | US | disclosed |
| WO-2022112919-A1 | (AZA)BENZOTHIAZOLYL SUBSTITUTED PYRAZOLE COMPOUNDS | PFIZER INC. (US) | 2022-06-02 | — | — | WO | disclosed |
| US-20220071965-A1 | Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent | PFIZER INC. (US) | 2022-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220071965-A1 | Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent | TTR, TTPA, GBA1 | TOP1 1751/4885ALOX15 349/4885SNCA 569/4885 |
| US-12268669-B2 | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent | TTR, TTPA, GBA1 | TOP1 1751/4885ALOX15 349/4885SNCA 569/4885 |
| US-20220184041-A1 | (AZA)Benzothiazolyl Substituted Pyrazole Compounds | TTR, APOB, SERPINB6 | TOP1 1003/4885ALOX15 1106/4885SNCA 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.