Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1357835 | 0.91 | ACACB (0.37) | — | |
| SCHEMBL1360760 | 0.90 | HTR2C (0.36) | CYP3A4HTR2CCHEK1 | |
| SCHEMBL1358011 | 0.90 | CYP3A4 (0.37) | CYP3A4HTR2CCHEK1RBP4 | |
| SCHEMBL1359499 | 0.90 | CYP3A4 (0.37) | CYP3A4HTR2CCHEK1RBP4 | |
| SCHEMBL1360466 | 0.89 | CHEK1 (0.37) | CYP3A4HTR2CCHEK1RBP4 | |
| SCHEMBL3144840 | 0.89 | CHEK1 (0.37) | CYP3A4HTR2CCHEK1RBP4 | |
| SCHEMBL1360367 | 0.89 | CYP3A4 (0.34) | CYP3A4HTR2C | |
| SCHEMBL1360041 | 0.89 | CYP3A4 (0.34) | CYP3A4HTR2C | |
| SCHEMBL1360027 | 0.88 | NPY5R (0.33) | KCNH2CYP3A4 | |
| SCHEMBL1359038 | 0.87 | NPC1L1 (0.39) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067442-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2011-11-29 | — | — | US | claimed |
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-04-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | EIF2AK2, POLR2A, HCCS | KCNH2 3465/4885CYP3A4 713/4885HTR2C 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.