Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596088 | 0.89 | ACHE (0.46) | ACHEBCHE | |
| SCHEMBL13596086 | 0.85 | ACHE (0.41) | ACHEBCHE | |
| SCHEMBL13596102 | 0.81 | ACHE (0.47) | ACHEBCHE | |
| SCHEMBL13596090 | 0.80 | ACHE (0.46) | ACHEBCHEGSK3B | |
| SCHEMBL4127320 | 0.78 | ACHE (0.38) | ACHEBCHE | |
| SCHEMBL13596027 | 0.77 | ACHE (0.52) | ACHEBCHE | |
| SCHEMBL4126649 | 0.76 | GPR119 (0.39) | ACHE | |
| SCHEMBL13596122 | 0.74 | ACHE (0.44) | ACHEBCHE | |
| SCHEMBL4135341 | 0.73 | ACHE (0.42) | ACHEBCHE | |
| SCHEMBL4120249 | 0.73 | FAAH (0.41) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | ACHE 3716/4885BCHE 2215/4885GSK3B 3423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.