Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 9/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601358 | 0.83 | ALDH1A1 (0.64) | SLC6A7KDM4EALDH1A1TSHRRECQL | |
| SCHEMBL3574729 | 0.80 | SLC6A7 (1.00) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL13117434 | 0.80 | HPGD (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL3582408 | 0.78 | SLC6A7 (0.74) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL4317911 | 0.78 | L3MBTL1 (0.57) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL3579391 | 0.76 | L3MBTL1 (0.65) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL13601231 | 0.76 | ALDH1A1 (0.69) | SLC6A7KDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL3585866 | 0.76 | SLC6A7 (0.76) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL3583409 | 0.76 | SLC6A7 (0.72) | SLC6A7KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL13117437 | 0.76 | KDM4C (0.59) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | SLC6A7 234/4885KDM4E 1411/4885L3MBTL1 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.