Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601661 | 0.94 | HTR2C (0.51) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL13601654 | 0.90 | TSHR (0.51) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL4685619 | 0.86 | ALDH1A1 (0.46) | LMNAPOLBTSHRALDH1A1L3MBTL1 | |
| SCHEMBL13601667 | 0.84 | TSHR (0.42) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL17557999 | 0.83 | HRH2 (0.52) | LMNAPOLBTSHRHRH2HRH1 | |
| SCHEMBL12881491 | 0.82 | GNAI3 (0.69) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL13601627 | 0.82 | NPC1 (0.58) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL12881511 | 0.82 | GNAI3 (0.51) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL12881522 | 0.82 | GNAI3 (0.51) | LMNAPOLBTSHRALDH1A1GNAI3 | |
| SCHEMBL23484812 | 0.81 | GNAI3 (0.51) | ALDH1A1GNAI3GNAI1GNAO1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |