Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601659 | 0.90 | LMNA (0.49) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601661 | 0.88 | HTR2C (0.51) | TSHRLMNAPOLBALDH1A1GNAI3 | |
| SCHEMBL13601664 | 0.83 | DNM1 (0.46) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4685619 | 0.83 | ALDH1A1 (0.46) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL17557992 | 0.81 | HRH2 (0.47) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601626 | 0.81 | NPC1 (0.57) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12259096 | 0.80 | GLA (0.54) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL19901120 | 0.80 | TSHR (0.42) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601667 | 0.80 | TSHR (0.42) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL123476 | 0.79 | THRB (0.48) | TSHRLMNAALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |