Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601729 | 0.90 | MAPT (0.39) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL12881480 | 0.88 | MAPT (0.43) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL12881488 | 0.87 | ACHE (0.43) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL12881497 | 0.86 | L3MBTL1 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL13601693 | 0.82 | MAPT (0.46) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL13601724 | 0.81 | MAPT (0.44) | MAPTHTR1AGAACYP1A2TDP1 | |
| SCHEMBL12881477 | 0.79 | GNAI3 (0.42) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL12881484 | 0.79 | ACHE (0.41) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL13601726 | 0.78 | SMN1; SMN2 (0.45) | MAPTHTR1AGAACYP1A2TDP1 | |
| SCHEMBL12881494 | 0.78 | L3MBTL1 (0.42) | CHRM2CHRM4CHRM1CHRM3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |