Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021882 | 0.87 | CA2 (0.53) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL27741035 | 0.84 | CA2 (0.56) | CA2CA1NAMPTTDP1MAPT | |
| Iodide SCHEMBL482058 | 0.83 | APOBEC3A (0.50) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL5264226 | 0.83 | CA2 (0.58) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL572740 | 0.83 | IDO1 (0.60) | CA2CA1NAMPTMAPTIDO1 | |
| SCHEMBL100146 | 0.81 | KDM4E (0.60) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL1569661 | 0.81 | CA2 (0.56) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL12283041 | 0.81 | NPC1 (0.60) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL30048842 | 0.81 | CA2 (0.59) | CA2CA1NAMPTTDP1MAPT | |
| SCHEMBL23449213 | 0.80 | CA2 (0.58) | CA2CA1NAMPTTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635775-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |