Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480475 | 0.83 | SIRT2 (0.46) | BRD4SIRT2CYP17A1 | |
| SCHEMBL5928116 | 0.81 | POLB (0.48) | POLBRAB9AALDH1A1 | |
| SCHEMBL13604730 | 0.80 | CYP11B1 (0.46) | MEN1TSHRKMT2ABRD4MAPT | |
| SCHEMBL13604333 | 0.80 | MEN1 (0.59) | MEN1TSHRKMT2ABRD4MKNK1 | |
| SCHEMBL13604582 | 0.78 | PARP1 (0.39) | SIRT2 | |
| SCHEMBL13604334 | 0.77 | KMT2A (0.62) | MEN1TSHRKMT2ABRD4MKNK1 | |
| SCHEMBL13604350 | 0.75 | MEN1 (0.63) | MEN1TSHRKMT2ABRD4MAPT | |
| SCHEMBL13604352 | 0.74 | MEN1 (0.55) | MEN1TSHRKMT2ABRD4MKNK1 | |
| SCHEMBL10391003 | 0.73 | ALDH1A1 (0.58) | MEN1TSHRKMT2ANPSR1HSD17B10 | |
| SCHEMBL6496747 | 0.72 | CYP11B1 (0.63) | MAPTPOLBCYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |