Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GLS | O94925 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476784 | 0.83 | BRD4 (0.51) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL13604333 | 0.80 | MEN1 (0.59) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL28745595 | 0.78 | RORC (0.46) | KMT2ATSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL14987165 | 0.77 | GLS (0.57) | KMT2AMEN1LMNAALDH1A1GLS | |
| SCHEMBL14987181 | 0.77 | GLS (0.57) | LMNAALDH1A1SMN1; SMN2GLS | |
| SCHEMBL13604331 | 0.77 | MEN1 (0.55) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL14987646 | 0.76 | GLS (0.56) | LMNAALDH1A1SMN1; SMN2GLSRAB9A | |
| SCHEMBL13604350 | 0.75 | MEN1 (0.63) | KMT2AMEN1TSHRPOLBBRD4 | |
| SCHEMBL7819834 | 0.75 | HSD17B10 (0.50) | KMT2AMEN1TSHRALDH1A1HSD17B10 | |
| SCHEMBL13604352 | 0.74 | MEN1 (0.55) | KMT2AMEN1TSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |