Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13608268 | 0.91 | MEN1 (0.39) | TGFBR1ACVR1MEN1KMT2ATRPV3 | |
| SCHEMBL13608348 | 0.89 | TGFBR1 (0.43) | TGFBR1ACVR1CNR2MEN1KMT2A | |
| SCHEMBL13608346 | 0.87 | GABRA1 (0.43) | TGFBR1ACVR1MEN1KMT2AMAP4K4 | |
| SCHEMBL13608355 | 0.84 | GABRA1 (0.41) | TGFBR1ACVR1MEN1KMT2ATRPV3 | |
| SCHEMBL13608258 | 0.84 | GABRA1 (0.48) | TGFBR1ACVR1MEN1KMT2AMAP4K4 | |
| SCHEMBL13608369 | 0.84 | PDGFRB (0.45) | TGFBR1ACVR1MEN1KMT2AGABRA1 | |
| SCHEMBL4057703 | 0.84 | AURKA (0.44) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL13608623 | 0.83 | ALOX5AP (0.39) | ALOX5APFEN1AMY1AAKR1C3AKR1C2 | |
| SCHEMBL13608354 | 0.82 | MEN1 (0.39) | TGFBR1ACVR1MEN1KMT2AMAP4K4 | |
| SCHEMBL13608360 | 0.82 | TRPA1 (0.41) | TGFBR1ACVR1MEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |