Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13607867 | 0.85 | PDE10A (0.40) | LMNAKDM4EMAPTPDE10ACDK1 | |
| SCHEMBL13608657 | 0.84 | CSNK2A2 (0.43) | AXLCDK8LMNAMAPTPDE10A | |
| SCHEMBL13607972 | 0.84 | RAB9A (0.51) | AXLCDK8LMNAMAPTPDE10A | |
| SCHEMBL13608641 | 0.84 | TUBB4A (0.49) | AXLCDK8MAPTPDE10ACDK1 | |
| SCHEMBL13608646 | 0.83 | MAPT (0.40) | AXLLMNAKDM4EMAPTPDE10A | |
| SCHEMBL13608625 | 0.83 | PDGFRB (0.46) | LMNAKDM4EMAPTPDE10ANOS3 | |
| SCHEMBL13608647 | 0.81 | HIF1A (0.47) | HIF1ACDK8LMNAMAPTPDE10A | |
| SCHEMBL4054780 | 0.80 | NOS3 (0.57) | HIF1ALMNAPDE10APRKAG1PRKAA2 | |
| SCHEMBL13608709 | 0.79 | RAB9A (0.52) | HIF1AAXLCDK8LMNAKDM4E | |
| SCHEMBL13608653 | 0.79 | NTRK1 (0.46) | AXLCDK8MAPTPDE10ACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |