Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 3/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.37 |
| ▸ | STS | P08842 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | OGG1 | O15527 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241834 | 0.84 | PPARA (0.44) | KMT2ALMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1359818 | 0.82 | APP (0.46) | APPKMT2ALMNAGRNSORT1 | |
| SCHEMBL5914739 | 0.79 | APP (0.41) | APPKMT2ALMNAGRNSORT1 | |
| SCHEMBL1359816 | 0.78 | APP (0.40) | APPKMT2ALMNAGRNSORT1 | |
| SCHEMBL11276032 | 0.67 | CYP3A4 (0.42) | KMT2ALMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL5914742 | 0.67 | MAPT (0.43) | LMNACYP3A4CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL18243873 | 0.67 | APP (0.39) | APPGRNSORT1STSCYP2D6 | |
| SCHEMBL11513712 | 0.67 | OGG1 (0.49) | KMT2ACNR2OGG1CYP2C19MAPT | |
| SCHEMBL11283460 | 0.67 | TSHR (0.38) | OGG1CYP3A4CYP2D6MAPT | |
| SCHEMBL3844831 | 0.66 | TPMT (0.46) | APPKMT2AGRNSORT1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067592-B2 | N-alkyny-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |
| US-7956188-B2 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| EP-1638928-B1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LTD (GB) | 2010-09-29 | — | — | EP | disclosed |
| EP-1817309-B1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-12-23 | — | — | EP | disclosed |
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| EP-1817309-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | Syngeta Participations AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20060217346-A1 | Fungicides | SYNGENTA LIMITED (GB) | 2006-09-28 | — | — | US | disclosed |
| WO-2006058700-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-08 | — | — | WO | disclosed |
| EP-1638928-A1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | Syngenta Limited (GB) | 2006-03-29 | — | — | EP | disclosed |
| EP-1567006-A1 | FUNGICIDES | Syngenta Limited (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004108663-A1 | N-ALKYNYL-2- (SUBSTITUTED ARYLOXY) ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |
| WO-2004052100-A1 | FUNGICIDES | SYNGENTA LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | NAT1, DPM1, AADAC | APP 4214/4885KMT2A 66/4885LMNA 4617/4885 |
| US-20060217346-A1 | Fungicides | CYP51A1, CYP4X1, CYP1A2 | APP 4375/4885KMT2A 2348/4885LMNA 4406/4885 |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | NAT1, AKR7A2, KCNA2 | APP 4103/4885KMT2A 227/4885LMNA 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.