Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13610554 | 0.82 | HSP90AB1 (0.47) | GAAALDH1A1GFERHTR7HSP90AB1 | |
| SCHEMBL20861827 | 0.80 | MYC (0.50) | GAAALDH1A1GFERHTR7HSP90AB1 | |
| SCHEMBL4382362 | 0.80 | MAPK14 (0.46) | ALDH1A1HTR7MAPK14MAPTHPGD | |
| SCHEMBL2707694 | 0.72 | ALDH1A1 (0.56) | ALDH1A1MAPK14MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2127019 | 0.72 | GAA (0.68) | GAAALDH1A1GFERHSP90AB1MAPT | |
| SCHEMBL30096935 | 0.72 | GAA (0.68) | GAAALDH1A1GFERHSP90AB1MAPT | |
| SCHEMBL14712149 | 0.71 | ALDH1A1 (0.53) | GAAALDH1A1GFERHSP90AB1MAPT | |
| SCHEMBL27758375 | 0.69 | MYC (0.38) | ALDH1A1MAPK14L3MBTL1KMT2AROCK2 | |
| SCHEMBL334348 | 0.69 | GAA (0.63) | GAAALDH1A1GFERHSP90AB1MAPT | |
| SCHEMBL1786183 | 0.69 | NPC1 (0.63) | GAAALDH1A1GFERHTR7HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |