SCHEMBL2127019

SCHEMBL2127019

COC(=O)Cc1ccc(O)c(C)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.68
ALDH1A1 P00352 3/20 0.68
GFER P55789 1/20 0.68
ESR1 P03372 1/20 0.55
ESR2 Q92731 1/20 0.55
HSP90AB1 P08238 1/20 0.55
CYP4F2 P78329 1/20 0.51
CYP4A11 Q02928 1/20 0.51
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 3/20 0.47
NFKB1 P19838 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
HPGD P15428 4/20 0.47
MAPT P10636 2/20 0.47
YWHAG P61981 1/20 0.46
SLC7A5 Q01650 1/20 0.44
KDM4E B2RXH2 2/20 0.43
GLA P06280 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30096935 1.00 GAA (0.68) GAAALDH1A1GFERESR1ESR2
SCHEMBL5539005 0.87 ALDH1A1 (0.56) GAAALDH1A1GFERESR1ESR2
SCHEMBL334348 0.86 GAA (0.63) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL29446278 0.85 GAA (0.72) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL3668882 0.85 GAA (0.72) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL1786183 0.85 NPC1 (0.63) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL3649411 0.84 ESR1 (0.53) GAAALDH1A1GFERESR1ESR2
Methyl Alcohol SCHEMBL27946196 0.84 GAA (0.70) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL14768426 0.84 GAA (0.70) GAAALDH1A1GFERHSP90AB1CYP4F2
SCHEMBL8736655 0.83 ESR2 (0.52) GAAALDH1A1GFERESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132121-A1 INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF ODYSSEY THERAPEUTICS INC (US) 2026-05-14 US disclosed
US-12624018-B1 Inhibitors of RIPK2 and medical uses thereof ODYSSEY THERAPEUTICS, INC. (US) 2026-05-12 US disclosed
EP-3947334-B1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS GIVAUDAN SA (CH) 2025-10-29 EP disclosed
EP-4622970-A1 INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2025-10-01 EP disclosed
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. 2025-05-22 US disclosed
US-12195698-B2 Fragrance compound providing lily of the valley fragrance characteristics, and fragranced compositions comprising the same GIVAUDAN SA (CH) 2025-01-14 US disclosed
US-20240424111-A1 Degrader Compounds and Uses Thereof CALICO LIFE SCIENCES LLC (US) 2024-12-26 US disclosed
WO-2024112854-A1 INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2024-05-30 WO disclosed
EP-4359409-A1 DEGRADER COMPOUNDS AND USES THEREOF Calico Life Sciences LLC (US) 2024-05-01 EP disclosed
EP-4359381-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-05-01 EP disclosed
US-7608639-B2 Phenoxyether derivatives as PPAR modulators ELI LILLY AND COMPANY (US) 2009-10-27 US disclosed
CN-101143529-A Heat-sensitive recording material RICOH KK (JP) 2008-03-19 CN disclosed
US-20070043003-A1 Novel compounds for the prophylaxis and treatment of inflammatory bowel diseases HIKMA PHARMACEUTICALS CO., LTD. (JO) 2007-02-22 US disclosed
US-20070037812-A1 Such as 3-{4-[3-(4-Chloro-2- phenoxy-phenoxy)- phenoxy]-2-methyl- phenyl}-propionic acid; peroxisome proliferator activated receptor (PPAR); syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis ELI LILLY AND COMPANY (US) 2007-02-15 US disclosed
EP-1675814-A1 PHENOXYETHER DERIVATIVES AS PPAR MODULATORS ELI LILLY AND COMPANY (US) 2006-07-05 EP disclosed
WO-2005037763-A1 PHENOXYETHER DERIVATIVES AS PPAR MODULATORS ELI LILLY AND COMPANY (US) 2005-04-28 WO disclosed
US-6376512-B1 FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-23 US disclosed
EP-0315399-B1 Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same RHONE POULENC RORER INT (US) 1996-01-10 EP disclosed
US-5059610-A QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1991-10-22 US disclosed
US-4920132-A Quinoline derivatives and use thereof as antagonists of leukotriene D4 RORER PHARMACEUTICAL CORP. (US) 1990-04-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF CBLB, CBL, CBLC GAA 1357/4885ALDH1A1 4185/4885GFER 3519/4885
US-12195698-B2 Fragrance compound providing lily of the valley fragrance characteristics, and fragranced compositions comprising the same MDH2, MDH1, TRPV1 GAA 3886/4885ALDH1A1 237/4885GFER 2042/4885
US-20240424111-A1 Degrader Compounds and Uses Thereof PTPN1, PTPN2, PTPN5 GAA 167/4885ALDH1A1 2830/4885GFER 720/4885
US-20070037812-A1 Such as 3-{4-[3-(4-Chloro-2- phenoxy-phenoxy)- phenoxy]-2-methyl- phenyl}-propionic acid; peroxisome proliferator activated receptor (PPAR); syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis PPARA, PPARG, PPARD GAA 1467/4885ALDH1A1 1232/4885GFER 2485/4885
US-20260132121-A1 INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF RIPK1, RIPK2, RIPK4 GAA 3362/4885ALDH1A1 4827/4885GFER 4585/4885
US-20070043003-A1 Novel compounds for the prophylaxis and treatment of inflammatory bowel diseases SI, ALPI, VIP GAA 401/4885ALDH1A1 302/4885GFER 1231/4885
US-12624018-B1 Inhibitors of RIPK2 and medical uses thereof RIPK2, RIPK1, RIPK4 GAA 3350/4885ALDH1A1 4801/4885GFER 4631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.