Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11771733 | 0.87 | LTA4H (0.46) | LTA4HALDH1A1CYP2D6ATMNPSR1 | |
| SCHEMBL10424271 | 0.82 | LTA4H (0.44) | LTA4HALDH1A1CYP2D6ATMSMN1; SMN2 | |
| SCHEMBL4439445 | 0.82 | ALDH1A1 (0.51) | LTA4HALDH1A1CYP2D6ATMNPSR1 | |
| SCHEMBL13604292 | 0.81 | LTA4H (0.43) | LTA4HALDH1A1CYP2D6ATMPOLB | |
| Hydrogen Sulfide SCHEMBL5799744 | 0.80 | LTA4H (0.56) | LTA4HALDH1A1CYP2D6ATML3MBTL1 | |
| SCHEMBL16020932 | 0.79 | MAPT (0.38) | ALDH1A1MAPTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL82538 | 0.79 | TAAR1 (0.43) | ALDH1A1L3MBTL1MAPK1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11105345 | 0.78 | ALDH1A1 (0.44) | LTA4HALDH1A1CYP2D6ATMNPSR1 | |
| Water SCHEMBL10981448 | 0.77 | TAAR1 (0.42) | ALDH1A1L3MBTL1MAPK1POLBSMN1; SMN2 | |
| Fluoride SCHEMBL28059937 | 0.76 | TAAR1 (0.41) | ALDH1A1L3MBTL1MAPK1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |