Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 8/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12206192 | 0.82 | MEN1 (0.50) | GRM5NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL13604293 | 0.81 | CYP17A1 (0.44) | CYP17A1CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL1136768 | 0.80 | CYP17A1 (0.51) | CYP17A1CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL26224097 | 0.80 | GRM5 (0.39) | GRM5PKMMAPTMEN1KMT2A | |
| SCHEMBL16020929 | 0.79 | KMT2A (0.52) | GRM5NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL10284918 | 0.79 | SMN1; SMN2 (0.55) | KDM4ENPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL13148615 | 0.79 | KMT2A (0.59) | SMN1; SMN2PKMMAPTMEN1KMT2A | |
| SCHEMBL4829111 | 0.79 | TSHR (0.45) | CYP17A1CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL2263697 | 0.79 | SLC6A3 (0.53) | GRM5SMN1; SMN2PKMMAPTMEN1 | |
| SCHEMBL10284720 | 0.79 | LTA4H (0.49) | GRM5NPC1PKMLTA4HMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |