Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300169 | 0.80 | KDR (0.51) | KDREGFRPDGFRBPDGFRATUBB3 | |
| SCHEMBL3237986 | 0.74 | EGFR (0.60) | KDREGFRMAPTACACAKDM4E | |
| SCHEMBL4647596 | 0.73 | KMT2A (0.59) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL13241207 | 0.72 | EGFR (0.50) | KDREGFRPDGFRBKDM4ESMN1; SMN2 | |
| SCHEMBL9975602 | 0.71 | MAPT (0.49) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL8271638 | 0.71 | ACACA (0.66) | MAPTACACAKDM4EMEN1KMT2A | |
| SCHEMBL20111051 | 0.71 | KDR (0.47) | KDREGFRPDGFRBPDGFRATUBB3 | |
| SCHEMBL18512973 | 0.70 | TUBB3 (0.43) | KDREGFRPDGFRBPDGFRATUBB3 | |
| SCHEMBL5277509 | 0.70 | CA4 (0.56) | KDREGFRPDGFRBKDM4EHPGD | |
| SCHEMBL9479727 | 0.70 | CA4 (0.56) | KDREGFRPDGFRBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008061112-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS INC (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008061112-A2 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MKI67, CCNI, CCNA1 | KDR 1693/4885EGFR 288/4885PDGFRB 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.