Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14433549 | 0.83 | TPSAB1 (0.39) | TPSAB1TPSD1TPSG1GAAITGB3 | |
| SCHEMBL10086273 | 0.83 | AKR1C3 (0.46) | AKR1C3SMN1; SMN2 | |
| SCHEMBL3904129 | 0.82 | AKR1C3 (0.44) | AKR1C3ITGB3ITGA2BNAMPTALDH1A1 | |
| SCHEMBL6179700 | 0.82 | ITGB3 (0.45) | ITGB3ITGA2B | |
| SCHEMBL14266466 | 0.81 | GAA (0.39) | TPSAB1TPSD1TPSG1GAANOS3 | |
| SCHEMBL13604410 | 0.79 | ITGB3 (0.39) | TPSAB1TPSD1TPSG1GAAITGB3 | |
| SCHEMBL14255273 | 0.79 | ITGB3 (0.37) | TPSAB1TPSD1TPSG1GAAITGB3 | |
| SCHEMBL12669611 | 0.79 | BRD4 (0.42) | TPSAB1TPSD1TPSG1GAAITGB3 | |
| SCHEMBL13611708 | 0.79 | AKR1C3 (0.39) | AKR1C3NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8280193 | 0.79 | GAA (0.43) | TPSAB1TPSD1TPSG1GAANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066515-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH | RECEPTOS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1423381-B1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES | SCHERING CORP (US) | 2007-01-03 | — | — | EP | disclosed |