Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268818 | 0.80 | NCF1 (0.48) | AKR1C3ALDH1A1 | |
| SCHEMBL13611685 | 0.79 | AKR1C3 (0.43) | AKR1C3NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10086273 | 0.78 | AKR1C3 (0.46) | AKR1C3EPHX1SMN1; SMN2 | |
| SCHEMBL14576723 | 0.78 | LIPA (0.38) | AKR1C3NAMPTEPHX1ALDH1A1 | |
| SCHEMBL15043693 | 0.78 | LIPA (0.38) | AKR1C3NAMPTEPHX1ALDH1A1 | |
| SCHEMBL526891 | 0.78 | — | — | |
| SCHEMBL13604910 | 0.78 | ITGB3 (0.32) | NAMPTALDH1A1 | |
| SCHEMBL3904129 | 0.77 | AKR1C3 (0.44) | AKR1C3NAMPTALDH1A1 | |
| SCHEMBL13617466 | 0.77 | SMN1; SMN2 (0.52) | AKR1C3EPHX1SMN1; SMN2 | |
| SCHEMBL6259294 | 0.75 | AKR1C3 (0.40) | AKR1C3NAMPTEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |