Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3911888 | 0.91 | MTNR1A (0.51) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL13626145 | 0.90 | MTNR1A (0.52) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL13612563 | 0.87 | HPGD (0.48) | PTGS1AKR1C3AKR1C2MTNR1ACYP1A2 | |
| SCHEMBL13626146 | 0.85 | MTNR1A (0.48) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL13612579 | 0.84 | CYP1A2 (0.56) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL3913720 | 0.82 | MTNR1A (0.68) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL13612568 | 0.81 | CYP1A2 (0.58) | MTNR1AHSD17B10CYP1A2CYP2C9TSHR | |
| SCHEMBL11780878 | 0.81 | PTGS1 (0.48) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 | |
| SCHEMBL13626838 | 0.80 | MTNR1A (0.53) | MTNR1ACYP1A2CYP2C9TSHRKMT2A | |
| SCHEMBL453836 | 0.80 | AKR1C2 (0.59) | PTGS1AKR1C3AKR1C2MTNR1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281154-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281154-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNN1, KCNN3, KCNN2 | PTGS1 68/4885AKR1C3 599/4885AKR1C2 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.