Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626837 | 0.91 | MTNR1A (0.49) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13626145 | 0.87 | MTNR1A (0.52) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13612562 | 0.85 | PTGS1 (0.52) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13626832 | 0.83 | MTNR1A (0.65) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13612563 | 0.80 | HPGD (0.48) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13612568 | 0.79 | CYP1A2 (0.58) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL13626838 | 0.78 | MTNR1A (0.53) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL3911888 | 0.76 | MTNR1A (0.51) | MTNR1ACYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7423539 | 0.74 | MTNR1A (0.56) | MTNR1ACYP1A2MTNR1BNQO2 | |
| SCHEMBL31618095 | 0.74 | MTNR1A (0.56) | MTNR1ACYP1A2MTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281154-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281154-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNN1, KCNN3, KCNN2 | MTNR1A 357/4885CYP1A2 3909/4885KMT2A 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.