SCHEMBL13613757

SCHEMBL13613757

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N(CCC(=O)CNC(=O)OCc1ccccc1)CC(=O)OC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSK P43235 10/20 0.47
CTSS P25774 4/20 0.47
CTSL P07711 3/20 0.47
CTSB P07858 2/20 0.47
MAPT P10636 1/20 0.45
XBP1 P17861 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
SYK P43405 1/20 0.43
CAPN1 P07384 1/20 0.43
CAPN2 P17655 1/20 0.43
PSEN1 P49768 2/20 0.42
PSEN2 P49810 2/20 0.42
APH1B Q8WW43 2/20 0.42
NCSTN Q92542 2/20 0.42
APH1A Q96BI3 2/20 0.42
PSENEN Q9NZ42 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4343773 0.94 CTSK (0.48) CTSKCTSSCTSLCTSBMAPT
SCHEMBL13613740 0.79 KLK7 (0.47) CTSKCTSSCTSLCTSBSYK
SCHEMBL16318175 0.76 CAPN1 (0.46) CTSKCTSSCTSLCTSBSYK
SCHEMBL18154376 0.76 CTSK (0.63) CTSKCTSSCTSLCTSBPOLB
SCHEMBL21885556 0.76 CTSK (0.63) CTSKCTSSCTSLCTSBPOLB
SCHEMBL10904441 0.76 CTSK (0.69) CTSKCTSSCTSLCTSBCAPN1
SCHEMBL5532444 0.76 PSEN1 (0.54) CTSKCTSSCTSLCTSBPSEN1
SCHEMBL4631066 0.76 PSEN1 (0.54) CTSKCTSSCTSLCTSBPSEN1
SCHEMBL3492066 0.76 PSEN1 (0.54) CTSKCTSSCTSLCTSBPSEN1
SCHEMBL13613765 0.76 SYK (0.46) CTSKCTSSCTSLCTSBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090275727-A1 Peptide turn mimetics MIMETICA PTY LIMITED (AU) 2009-11-05 US disclosed
US-20090275727-A1 Peptide turn mimetics MIMETICA PTY LIMITED (AU) 2009-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090275727-A1 Peptide turn mimetics IAPP, GLP1R, VIP CTSK 1231/4885CTSS 1601/4885CTSL 436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.