Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894844 | 0.87 | MEN1 (0.59) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| SCHEMBL496782 | 0.83 | MEN1 (0.55) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| SCHEMBL497459 | 0.81 | MEN1 (0.67) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| SCHEMBL1773389 | 0.80 | HTR6 (0.51) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1773252 | 0.77 | BRD4 (0.58) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL14687940 | 0.76 | MEN1 (0.47) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| SCHEMBL1082937 | 0.76 | BRD4 (0.54) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| SCHEMBL28735169 | 0.75 | MEN1 (0.52) | KMT2AMEN1PLK1LMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL1046149 | 0.75 | BRD4 (0.51) | PLK1LMNASMN1; SMN2BRD4HTR6 | |
| SCHEMBL2886421 | 0.74 | KMT2A (1.00) | KMT2AMEN1PLK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704147-B1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2009-11-04 | — | — | EP | disclosed |