Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26625068 | 0.82 | HTR6 (0.50) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL13613784 | 0.81 | KMT2A (0.59) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL1894844 | 0.81 | MEN1 (0.59) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL2886421 | 0.81 | KMT2A (1.00) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL496782 | 0.78 | MEN1 (0.55) | MEN1KMT2ALMNASMN1; SMN2PTGDR2 | |
| SCHEMBL1773129 | 0.78 | HTR6 (0.58) | LMNASMN1; SMN2HTR6PTGDR2SLC40A1 | |
| SCHEMBL2984205 | 0.78 | L3MBTL1 (0.55) | LMNASMN1; SMN2HTR6PTGDR2KDM4E | |
| SCHEMBL17394567 | 0.77 | HTR6 (0.58) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL28207078 | 0.76 | KMT2A (0.76) | MEN1KMT2ALMNASMN1; SMN2HTR6 | |
| SCHEMBL1267767 | 0.76 | CYP2C19 (0.56) | LMNASMN1; SMN2HTR6PTGDR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198298-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-8106069-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2012-01-31 | — | — | US | disclosed |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2011-06-09 | — | — | US | disclosed |
| US-7888508-B2 | 3-(carboxy or carbamoyl)-5-amino-1H-pyrrolo(2,3-b)pyridines; cancer, Alzheimer's disease, viral infections, autoimmune diseases and neurodegenerative disorders; chemical libraries of these compounds | PFIZER ITALIA S.R.L. (IT) | 2011-02-15 | — | — | US | disclosed |
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | PFIZER ITALIA S.R.L. (IT) | 2010-08-19 | — | — | US | disclosed |
| US-7728140-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2010-06-01 | — | — | US | disclosed |
| EP-1701956-B1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-02-24 | — | — | EP | disclosed |
| EP-1704147-B1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2009-11-04 | — | — | EP | disclosed |
| EP-1704147-A1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | Pfizer Italia S.r.l. (IT) | 2006-09-27 | — | — | EP | disclosed |
| EP-1701956-A1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Italia S.r.l. (IT) | 2006-09-20 | — | — | EP | disclosed |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-11-17 | — | — | US | disclosed |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-09-22 | — | — | US | disclosed |
| WO-2005063747-A1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA S.R.L. (IT) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005063746-A1 | PYRROLO[2,3-b]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA S.R.L. (IT) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | MAP3K6, MAP3K3, MAP3K1 | MEN1 2558/4885KMT2A 1717/4885LMNA 4001/4885 |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | MEN1 2469/4885KMT2A 1599/4885LMNA 3842/4885 |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K6, MAP3K3, MAP3K15 | MEN1 2478/4885KMT2A 1503/4885LMNA 4426/4885 |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | MEN1 2469/4885KMT2A 1599/4885LMNA 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.