Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23560422 | 0.88 | MTNR1B (0.57) | MEN1KMT2AMAPTMTNR1BALDH1A1 | |
| SCHEMBL3762312 | 0.86 | MEN1 (0.62) | NAMPTEPHX2NR1H4MEN1KMT2A | |
| SCHEMBL14559568 | 0.84 | SMN1; SMN2 (0.55) | MEN1KMT2AMTNR1BALDH1A1NPC1 | |
| SCHEMBL1840208 | 0.83 | HDAC1 (0.68) | NAMPTEPHX2NR1H4MEN1KMT2A | |
| SCHEMBL340246 | 0.82 | EPHX1 (0.64) | EPHX2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL13207187 | 0.82 | PLK1 (0.54) | NAMPTMEN1KMT2AMTNR1BNPC1 | |
| SCHEMBL4745756 | 0.82 | EPHX2 (0.71) | EPHX2NR1H4MEN1KMT2ACA12 | |
| SCHEMBL4958183 | 0.81 | NAMPT (0.58) | NAMPTEPHX2NR1H4MEN1KMT2A | |
| SCHEMBL2911571 | 0.81 | MAPK14 (0.51) | — | |
| SCHEMBL1977470 | 0.81 | MAOA (0.57) | EPHX2NR1H4MEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |