Sugi Predict

Sugi Predict / Compounds / SCHEMBL340246

SCHEMBL340246

SCHEMBL340246

CCNC(=O)Nc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX1 P07099 5/20 0.64
▸ SMN1; SMN2 Q16637 3/20 0.64
▸ TP53 P04637 2/20 0.64
▸ TSHR P16473 1/20 0.64
▸ EPHX2 P34913 1/20 0.64
▸ CDK9 P50750 1/20 0.64
▸ CLK4 Q9HAZ1 1/20 0.64
▸ ALDH1A1 P00352 2/20 0.64
▸ HTT P42858 2/20 0.64
▸ KDM4E B2RXH2 2/20 0.59
▸ L3MBTL1 Q9Y468 1/20 0.59
▸ NPC1 O15118 6/20 0.59
▸ RAB9A P51151 6/20 0.59
▸ KMT2A Q03164 3/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ HPGD P15428 1/20 0.59
▸ NOX1 Q9Y5S8 1/20 0.58
▸ TAAR1 Q96RJ0 1/20 0.57
▸ CYP2C19 P33261 1/20 0.56
▸ RECQL P46063 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9479531 0.93 CASP3 (0.69) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL10400585 0.90 EPHX1 (0.57) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL14045089 0.90 ALDH1A1 (0.65) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL23560422 0.89 MTNR1B (0.57) EPHX1ALDH1A1HTTNPC1RAB9A
SCHEMBL8906337 0.89 CASR (0.60) EPHX1SMN1; SMN2ALDH1A1HTTNPC1
SCHEMBL10926436 0.88 EPHX1 (0.60) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL10926799 0.85 EPHX1 (0.66) EPHX1SMN1; SMN2ALDH1A1HTTKDM4E
SCHEMBL2451040 0.84 EPHX1 (0.75) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL10927503 0.84 EPHX1 (0.56) EPHX1SMN1; SMN2TP53TSHREPHX2
SCHEMBL10926397 0.84 EPHX1 (0.64) EPHX1ALDH1A1HTTKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160109445-A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS FIRMENICH INCORPORATED 2016-04-21 — — US claimed
US-20140302528-A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS SENOMYX, INC. (US) 2014-10-09 — — US claimed
EP-2391666-B1 CROSS-LINKABLE AROMATIC POLYCARBONATE NEXAM CHEMICAL AB (SE) 2013-08-28 — — EP claimed
CN-101522631-B Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the ss2 adrenergic receptor ALMIRALL LAB 2013-06-12 — — CN claimed
US-20120015378-A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS SENOMYX, INC. 2012-01-19 — — US claimed
US-20110136112-A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS FIRMENICH INCORPORATED 2011-06-09 — — US claimed
WO-2010087742-A1 ACETYLENIC AROMATIC POLYCARBONATE NEXAM CHEMICAL AB (SE) 2010-08-05 — — WO claimed
CN-101522631-A Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the ss2 adrenergic receptor ALMIRALL LAB (ES) 2009-09-02 — — CN claimed
EP-2078081-A2 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS Senomyx, Inc. (US) 2009-07-15 — — EP claimed
US-20080306237-A1 Highly Functional, Highly Branched Polyureas BASF AKTIENGESELLSCHAFT (DE) 2008-12-11 — — US claimed
EP-1716197-B1 HIGHLY FUNCTIONAL, HIGHLY BRANCHED POLYUREAS BASF SE (DE) 2008-10-29 — — EP claimed
US-20080227999-A1 Heterogeneous Supported Catalytic Carbamate Process MOLZAHN DAVID C 2008-09-18 — — US claimed
US-20080187936-A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS SENOMYX, INC. (US) 2008-08-07 — — US claimed
WO-2008057470-A2 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS SENOMYX, INC. (US) 2008-05-15 — — WO claimed
US-20080038739-A1 For use in foods, beverages, cosmetics and drugs SENOMYX, INC. (US) 2008-02-14 — — US claimed
EP-0331052-A2 Process for the preparation of imidized acrylic polymers ELF ATOCHEM ITALIA S.r.l. (IT) 1989-09-06 — — EP claimed
US-4072712-A FROM ISOCYANATES, CATALYSIS BAYER AKTIENGESELLSCHAFT (DT) 1978-02-07 — — US claimed
EP-3921349-B1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC (US) 2026-01-14 — — EP disclosed
US-4072712-A FROM ISOCYANATES, CATALYSIS BAYER AKTIENGESELLSCHAFT (DT) 1978-02-07 — — US disclosed
US-3936484-A Production of isocyanates from substituted ureas ATLANTIC RICHFIELD COMPANY (US) 1976-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227999-A1 Heterogeneous Supported Catalytic Carbamate Process CPS1, CAT, CA7 EPHX1 4546/4885SMN1; SMN2 3171/4885TP53 1592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.