Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303777 | 0.81 | MPO (0.46) | KMT2AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL3691604 | 0.80 | NAAA (0.52) | KMT2ADRD2DRD4DRD3MEN1 | |
| SCHEMBL22059613 | 0.77 | EPHX2 (0.66) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL28803614 | 0.77 | XDH (0.68) | KMT2AMEN1ALDH1A1NAMPTHPGD | |
| SCHEMBL14430719 | 0.77 | MAPT (0.53) | KMT2AALDH1A1NAMPTGAAL3MBTL1 | |
| Andolast SCHEMBL166170 | 0.77 | XDH (0.51) | KMT2AKDM4EMEN1GAAL3MBTL1 | |
| SCHEMBL13918749 | 0.76 | KDM4E (0.70) | KMT2AKDM4EDRD2DRD4DRD3 | |
| SCHEMBL7432657 | 0.76 | XDH (0.51) | KMT2AHPGDL3MBTL1POLB | |
| Andolast SCHEMBL1551317 | 0.75 | XDH (0.50) | KMT2AKDM4EMEN1GAAL3MBTL1 | |
| Andolast SCHEMBL4134029 | 0.75 | XDH (0.50) | KMT2AKDM4EMEN1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |