Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12810441 | 0.86 | CA2 (0.70) | CA2LMNAPOLBESR2MTNR1A | |
| SCHEMBL438555 | 0.83 | CA2 (1.00) | CA2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL9413231 | 0.81 | CA2 (0.62) | CA2HTTPOLBESR2MTNR1A | |
| SCHEMBL7201020 | 0.75 | MTNR1A (0.74) | CA2LMNAHTTPOLBESR2 | |
| SCHEMBL9413211 | 0.74 | CA2 (0.58) | CA2HTTPOLBESR2MTNR1A | |
| SCHEMBL9413175 | 0.74 | POLB (0.74) | CA2HTTPOLBESR2MTNR1A | |
| SCHEMBL12309752 | 0.73 | POLB (0.62) | CA2HTTPOLBESR2MTNR1A | |
| SCHEMBL1568393 | 0.73 | HTT (0.66) | CA2HTTPOLBMTNR1AALDH1A1 | |
| SCHEMBL28773753 | 0.73 | CA2 (0.68) | CA2LMNAHTTPOLBMTNR1A | |
| SCHEMBL9316602 | 0.73 | CA2 (0.58) | CA2LMNAHTTPOLBESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973540-B1 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-11 | — | — | EP | disclosed |