Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457576 | 0.82 | MMP2 (0.54) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL2839000 | 0.82 | MMP1 (0.54) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL743961 | 0.80 | MMP13 (0.57) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL3597949 | 0.80 | MMP1 (0.53) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL2497828 | 0.80 | MMP1 (0.53) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL1244889 | 0.80 | MMP1 (0.53) | MMP1MMP2MMP9MMP13KDM4E | |
| Hydrochloric Acid SCHEMBL23120712 | 0.78 | MMP1 (0.51) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL28785165 | 0.77 | MMP13 (0.54) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL2142883 | 0.77 | MMP1 (0.50) | MMP1MMP2MMP9MMP13KDM4E | |
| SCHEMBL27427579 | 0.77 | MMP1 (0.50) | MMP1MMP2MMP9MMP13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |