SCHEMBL13616184

SCHEMBL13616184

CC(=O)NCCc1ncc(C(C)(C)C)o1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 12/20 0.48
CCNE2 O96020 10/20 0.48
CCNE1 P24864 10/20 0.48
CCNB2 O95067 5/20 0.48
CDK1 P06493 5/20 0.48
CCNB1 P14635 5/20 0.48
CCNB3 Q8WWL7 5/20 0.48
CDK4 P11802 5/20 0.48
CCND1 P24385 5/20 0.48
CCND3 P30281 4/20 0.48
CCND2 P30279 1/20 0.48
QPCT Q16769 1/20 0.42
QPCTL Q9NXS2 1/20 0.42
KDM4E B2RXH2 1/20 0.39
F13A1 P00488 1/20 0.39
MTNR1A P48039 2/20 0.38
HDAC3 O15379 3/20 0.38
HDAC4 P56524 3/20 0.38
CDK6 Q00534 3/20 0.38
HDAC1 Q13547 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL50579 0.81 CCNE2 (0.46) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL13188146 0.78 CDK2 (0.41) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL50534 0.78 CCNB2 (0.48) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL3711339 0.76 CCNE2 (0.57) CDK2CCNE2CCNE1
SCHEMBL3719448 0.76 RXRA (0.51) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL5725573 0.74 CCNE2 (0.65) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL3718311 0.73 RXRA (0.42) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL13189035 0.73 HDAC1 (0.42) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL22482074 0.72 MTNR1A (0.46) QPCTQPCTLKDM4EF13A1MTNR1A
SCHEMBL13827907 0.72 CDK2 (0.44) CDK2CCNE2CCNE1CCNB2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009133127-A1 FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS MERCK SERONO S.A. (CH) 2009-11-05 WO disclosed