⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31287637 | 0.85 | PLG (0.30) | — | |
| SCHEMBL3665243 | 0.78 | — | — | |
| SCHEMBL76463 | 0.76 | — | — | |
| SCHEMBL6379288 | 0.73 | — | — | |
| SCHEMBL24017656 | 0.71 | ALDH1A1 (0.36) | — | |
| SCHEMBL10920868 | 0.71 | — | — | |
| SCHEMBL15974686 | 0.71 | — | — | |
| SCHEMBL18967146 | 0.71 | ADH1B (0.36) | — | |
| SCHEMBL22552891 | 0.70 | — | — | |
| SCHEMBL22552959 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067409-B2 | Protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090253723-A1 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | US | disclosed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |