Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428991 | 0.94 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL4345132 | 0.94 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL3428994 | 0.94 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL4345140 | 0.94 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL13616369 | 0.92 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL3433228 | 0.92 | SENP1 (0.53) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL3433230 | 0.92 | SENP1 (0.53) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL13616359 | 0.91 | NPC1 (0.53) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL3427925 | 0.90 | RAB9A (0.62) | NPC1RAB9AKMT2AMEN1GRIN1 | |
| SCHEMBL3427921 | 0.90 | RAB9A (0.62) | NPC1RAB9AKMT2AMEN1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| WO-2009097695-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | CHLORION PHARMA, INC. (CA) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | OPRL1, OPRK1, AHR | NPC1 2712/4885RAB9A 4212/4885KMT2A 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.