Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928088 | 0.84 | KMT2A (0.43) | NQO2ALDH1A1CYP3A4MAPTTDP1 | |
| SCHEMBL6631046 | 0.84 | MAPT (0.57) | NQO2ALDH1A1CYP3A4MAPTTDP1 | |
| SCHEMBL19783368 | 0.78 | ALDH1A1 (0.44) | NQO2ALDH1A1CYP3A4MAPTHTT | |
| SCHEMBL18229829 | 0.77 | HSP90AA1 (0.41) | ALDH1A1CYP3A4MAPTHTTPKM | |
| SCHEMBL15007822 | 0.75 | MAPT (0.68) | NQO2ALDH1A1MAPTTDP1HTT | |
| SCHEMBL4816985 | 0.73 | ALDH1A1 (0.54) | ALDH1A1CYP3A4MAPTTDP1HTT | |
| SCHEMBL6628248 | 0.73 | MAPT (0.50) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2198619 | 0.72 | GPR35 (0.44) | ALDH1A1CYP3A4MAPTTDP1HTT | |
| SCHEMBL9147927 | 0.72 | ERN1 (0.48) | NQO2ALDH1A1MAPTTDP1HTT | |
| SCHEMBL15910493 | 0.71 | MAPT (0.51) | NQO2ALDH1A1CYP3A4MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067592-B2 | N-alkyny-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |
| US-7956188-B2 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| EP-1638928-B1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LTD (GB) | 2010-09-29 | — | — | EP | disclosed |
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| US-7371764-B2 | Quinolin-isoquinolin-and quinazolin-oxyalkylamides and their use as fungicides | SYNGENTA LIMITED (GB) | 2008-05-13 | — | — | US | disclosed |
| EP-1567010-B1 | QUINOLIN-, ISOQUINOLIN-, AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES | SYNGENTA LTD (GB) | 2007-10-24 | — | — | EP | disclosed |
| EP-1817309-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | Syngeta Participations AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| US-20070072884-A1 | QUINOLIN-ISOQUINOLIN-AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2007-03-29 | — | — | US | disclosed |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-7122672-B2 | Quinolin-, isoquinolin-, and quinazolin-oxyalkylamides and their use as fungicides | SYNGENTA LIMITED (GB) | 2006-10-17 | — | — | US | disclosed |
| WO-2006058700-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-08 | — | — | WO | disclosed |
| EP-1638928-A1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | Syngenta Limited (GB) | 2006-03-29 | — | — | EP | disclosed |
| US-20060019973-A1 | Quinolin-,isoquinolin-,and quinazolin-oxyalkylamides and their use as fungicides | SYNGENTA LIMITED (GB) | 2006-01-26 | — | — | US | disclosed |
| EP-1567010-A1 | QUINOLIN-, ISOQUINOLIN-, AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES | Syngenta Limited (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004108663-A1 | N-ALKYNYL-2- (SUBSTITUTED ARYLOXY) ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |
| WO-2004047538-A1 | QUINOLIN-, ISOQUINOLIN-, AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | NAT1, DPM1, AADAC | NQO2 246/4885ALDH1A1 895/4885CYP3A4 409/4885 |
| US-20070072884-A1 | QUINOLIN-ISOQUINOLIN-AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES | CBR3, CBR1, POR | NQO2 30/4885ALDH1A1 2830/4885CYP3A4 32/4885 |
| US-20060019973-A1 | Quinolin-,isoquinolin-,and quinazolin-oxyalkylamides and their use as fungicides | CYP4X1, CYP51A1, CYP1A2 | NQO2 9/4885ALDH1A1 896/4885CYP3A4 17/4885 |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | NAT1, AKR7A2, KCNA2 | NQO2 719/4885ALDH1A1 543/4885CYP3A4 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.