Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616488 | 0.91 | CYP1A2 (0.39) | SMN1; SMN2LMNAGAATHRBALDH1A1 | |
| SCHEMBL13616559 | 0.89 | GAA (0.46) | SMN1; SMN2LMNAGAATHRBALDH1A1 | |
| SCHEMBL13616487 | 0.80 | LMNA (0.47) | SMN1; SMN2LMNAGAAMAPK1L3MBTL1 | |
| SCHEMBL4317015 | 0.73 | CYP1A2 (0.41) | SMN1; SMN2LMNAALDH1A1MAPK1MAPT | |
| SCHEMBL13616568 | 0.72 | MAPK1 (0.43) | SMN1; SMN2LMNAGAAALDH1A1MAPK1 | |
| SCHEMBL13616475 | 0.71 | HDAC3 (0.43) | SMN1; SMN2LMNAGAAALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL9848168 | 0.71 | NPC1 (0.46) | SMN1; SMN2LMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL13616564 | 0.68 | DRD2 (0.44) | KMT2A | |
| SCHEMBL13616566 | 0.67 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAGAATHRBALDH1A1 | |
| SCHEMBL13616567 | 0.67 | MAPK1 (0.49) | SMN1; SMN2LMNAGAATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | RIF1, ABCC1, HDAC6 | SMN1; SMN2 4789/4885LMNA 2521/4885GAA 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.