Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616492 | 0.89 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1MEN1KMT2APDE4B | |
| SCHEMBL13616491 | 0.77 | MAPT (0.63) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL13616475 | 0.77 | HDAC3 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL13616567 | 0.74 | MAPK1 (0.49) | SMN1; SMN2ALDH1A1MAPK1L3MBTL1TDP1 | |
| SCHEMBL11627964 | 0.73 | L3MBTL1 (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL13616568 | 0.72 | MAPK1 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL11625921 | 0.72 | MAPT (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2APDE4B | |
| SCHEMBL13616564 | 0.70 | DRD2 (0.44) | MEN1KMT2A | |
| SCHEMBL13616570 | 0.68 | NOTUM (0.51) | MAPK1L3MBTL1TDP1GAA | |
| SCHEMBL13616560 | 0.67 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | RIF1, ABCC1, HDAC6 | SMN1; SMN2 4789/4885ALDH1A1 1070/4885MEN1 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.