Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amiphenazole SCHEMBL139210 | 0.79 | ALDH1A1 (0.68) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL11753179 | 0.78 | ALDH1A1 (0.60) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| Amiphenazole SCHEMBL4381796 | 0.78 | ALDH1A1 (0.66) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL544628 | 0.78 | ADORA3 (0.52) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| Amiphenazole SCHEMBL18642505 | 0.77 | ALDH1A1 (0.59) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL11752472 | 0.77 | ALDH1A1 (0.71) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL11747898 | 0.77 | ALDH1A1 (0.71) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL11964993 | 0.76 | ALOX5 (0.61) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL6800972 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| Amiphenazole SCHEMBL1648767 | 0.76 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |