Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857699 | 0.87 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL1114114 | 0.87 | SLC6A3 (0.63) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL22335527 | 0.77 | SLC6A2 (0.40) | SLC6A3SLC6A2SLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL6499702 | 0.77 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4TDP1 | |
| SCHEMBL524482 | 0.76 | SLC6A3 (0.63) | SLC6A3SLC6A2SLC6A4MAPT | |
| SCHEMBL6503574 | 0.76 | SLC6A3 (0.75) | SLC6A3SLC6A2SLC6A4TDP1 | |
| SCHEMBL20366936 | 0.75 | ALDH1A1 (0.36) | SLC6A3SLC6A2SLC6A4ALDH1A1MAPT | |
| SCHEMBL22325333 | 0.74 | SLC6A3 (0.60) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL30857682 | 0.73 | SLC6A3 (0.63) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL16037864 | 0.73 | SLC6A3 (0.43) | SLC6A3SLC6A2SLC6A4MAPTCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |