Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19768916 | 0.81 | CNR1 (0.43) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11610011 | 0.79 | BRD4 (0.56) | LMNAMEN1KMT2APKMALDH1A1 | |
| SCHEMBL24666193 | 0.76 | MAPT (0.40) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20326799 | 0.76 | MEN1 (0.43) | MEN1KMT2APKMKDM4EALDH1A1 | |
| SCHEMBL2495583 | 0.76 | GPR35 (0.39) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL12659545 | 0.75 | RAPGEF4 (0.36) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11607380 | 0.74 | KDM4E (0.47) | LMNAKMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8496458 | 0.74 | PTGER3 (0.53) | LMNABRD4MAPTHTT | |
| SCHEMBL12659546 | 0.73 | PDE10A (0.33) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1548236 | 0.73 | LMNA (0.49) | LMNAKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |