Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.56 |
| ▸ | CA2 | P00918 | 5/20 | 0.56 |
| ▸ | CA9 | Q16790 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138895 | 0.97 | CA2 (0.58) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL17456405 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL8058040 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL10359279 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL28760627 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL1115426 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL944250 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| Water SCHEMBL2134977 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL17456525 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 | |
| SCHEMBL11427595 | 0.95 | CA1 (0.56) | CA1CA2CA9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067462-B2 | Processes of making sesquiterpenoid tashironin, its analogs and their uses | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090105332-A1 | PROCESSES OF MAKING SESQUITERPENOID TASHIRONIN, ITS ANALOGS AND THEIR USES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF (US) | 2009-04-23 | — | — | US | disclosed |
| US-7186854-B2 | Process for making bicalutamide and intermediates thereof | SYNTHON IP INC. (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1546093-A1 | PROCESS FOR MAKING BICALUTAMIDE AND INTERMEDIATES THEREOF | Synthon B.V. (NL) | 2005-06-29 | — | — | EP | disclosed |
| US-6818766-B2 | USING P-FLUOROBENZENESULFINIC ACID | SYNTHON BV (NL) | 2004-11-16 | — | — | US | disclosed |
| WO-2004031136-A1 | PROCESS FOR MAKING BICALUTAMIDE AND INTERMEDIATES THEREOF | SYNTHON B.V. (NL) | 2004-04-15 | — | — | WO | disclosed |
| US-20030073742-A1 | Process for making bicalutamide and intermediates thereof | SYNTHON B.V. (NL) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073742-A1 | Process for making bicalutamide and intermediates thereof | BLVRB, BRDT, OTUB1 | CA1 251/4885CA2 757/4885CA9 94/4885 |
| US-20090105332-A1 | PROCESSES OF MAKING SESQUITERPENOID TASHIRONIN, ITS ANALOGS AND THEIR USES | OXER1, OXSR1, BRS3 | CA1 1059/4885CA2 1277/4885CA9 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.