Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845713 | 0.91 | CPB2 (0.45) | CPB2CPB1AKT1 | |
| SCHEMBL8345705 | 0.89 | KLK5 (0.49) | KLK5SIRT2CPB2CPB1AKT1 | |
| SCHEMBL16464699 | 0.85 | HDAC6 (0.60) | HDAC6HDAC1NLRP3KLK5TACR1 | |
| SCHEMBL16464697 | 0.85 | HDAC6 (0.60) | HDAC6HDAC1NLRP3KLK5TACR1 | |
| SCHEMBL8347877 | 0.84 | CPB2 (0.54) | KLK5SIRT2CPB2CPB1TACR1 | |
| SCHEMBL19508750 | 0.82 | KLK5 (0.51) | KLK5SIRT2AKT1 | |
| SCHEMBL8349511 | 0.82 | CPB2 (0.42) | KLK5SIRT2CPB2CPB1TACR1 | |
| SCHEMBL6324267 | 0.81 | ACE (0.52) | CPB2CPB1AKT1 | |
| SCHEMBL8364520 | 0.79 | CPB2 (0.37) | KLK5CPB2CPB1TACR1AKT1 | |
| SCHEMBL13617417 | 0.78 | CPB2 (0.48) | KLK5SIRT2CPB2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |