Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324267 | 0.92 | ACE (0.52) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL19508750 | 0.90 | KLK5 (0.51) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL13617435 | 0.89 | HDAC6 (0.46) | KLK5AKT1SIRT2CPB2CPB1 | |
| SCHEMBL8347877 | 0.86 | CPB2 (0.54) | KLK5CTSKSCN9ASIRT2CPB2 | |
| SCHEMBL8349511 | 0.84 | CPB2 (0.42) | KLK5CTSKSIRT2CPB2CPB1 | |
| SCHEMBL5358340 | 0.82 | MAPT (0.46) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL4418364 | 0.82 | ALDH1A1 (0.45) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL27627317 | 0.82 | ALDH1A1 (0.45) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL17642069 | 0.82 | ACE (0.56) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL3429311 | 0.82 | ACE (0.56) | CTSSCTSKCTSLCTSBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003061653-A9 | 3-(IMIDAZOLYL)-2-AMINOPROPANOIC ACIDS FOR USE AS TAFI-A INHIBITORS FOR THE TREATMENT OF THROMBOTIC DISEASES | PFIZER LTD (GB) | 2003-12-24 | — | — | WO | disclosed |