Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 6/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65300 | 0.82 | HTR2A (0.32) | HTR2CHTR2BHTR2A | |
| SCHEMBL21601405 | 0.76 | TAAR1 (0.48) | PLAUPARP1PARP3TAAR1KDM4E | |
| SCHEMBL24096249 | 0.76 | TAAR1 (0.48) | PLAUPARP1PARP3TAAR1KDM4E | |
| SCHEMBL773452 | 0.74 | TSHR (0.47) | — | |
| Hydrochloric Acid SCHEMBL7484053 | 0.74 | KDM4E (0.52) | PARP1TAAR1KDM4EHTR2CHTR2B | |
| SCHEMBL91267 | 0.72 | LMNA (0.43) | KDM4E | |
| SCHEMBL661082 | 0.72 | REN (0.40) | TAAR1HTR2AREN | |
| SCHEMBL7606607 | 0.72 | REN (0.41) | TAAR1REN | |
| SCHEMBL78179 | 0.71 | KDM4E (0.43) | KDM4E | |
| SCHEMBL27337036 | 0.71 | HTR2A (0.31) | PLAUPARP1PARP3HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888538-B1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |