Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617547 | 0.82 | PLAU (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL3119777 | 0.77 | SCN8A (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27337036 | 0.77 | HTR2A (0.31) | HTR2AHTR2CHTR2B | |
| SCHEMBL661082 | 0.74 | REN (0.40) | HTR2A | |
| SCHEMBL27341101 | 0.71 | TDP1 (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL9142141 | 0.71 | — | — | |
| SCHEMBL91267 | 0.71 | LMNA (0.43) | CYP2D6 | |
| SCHEMBL7606607 | 0.71 | REN (0.41) | — | |
| SCHEMBL16178976 | 0.71 | SCN8A (0.33) | — | |
| SCHEMBL78179 | 0.70 | KDM4E (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |