Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 3/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127328 | 0.82 | NOTUM (0.70) | DHODHNOTUMKMOPIN1CCNC | |
| SCHEMBL25180562 | 0.80 | NOTUM (0.68) | NOTUMKMOPIN1CCNCCDK8 | |
| SCHEMBL13175902 | 0.80 | NOTUM (0.54) | DHODHNOTUMKMOPIN1ICMT | |
| SCHEMBL11166619 | 0.80 | AKR1C2 (0.54) | DHODHKMOAKR1C2AKR1C1PIN1 | |
| SCHEMBL121813 | 0.77 | KMO (0.68) | DHODHKMOAKR1C2AKR1C1CNR2 | |
| SCHEMBL27582159 | 0.76 | RAB9A (0.43) | DHODHKMOPIN1 | |
| SCHEMBL5397397 | 0.76 | ADORA1 (0.66) | KMO | |
| SCHEMBL14800575 | 0.74 | NOTUM (0.47) | NOTUMAKR1C2AKR1C1CCNCCDK8 | |
| SCHEMBL31178157 | 0.74 | TP53 (0.71) | KMO | |
| SCHEMBL30874537 | 0.74 | SMN1; SMN2 (0.56) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |