Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630202 | 0.91 | ADRB2 (0.43) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL13617663 | 0.91 | ADRB2 (0.44) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL13697685 | 0.90 | ADRB2 (0.42) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL16066905 | 0.90 | ADRB2 (0.42) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL18601883 | 0.90 | ADRB2 (0.42) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL18946383 | 0.82 | ADRB2 (0.48) | ADRB2ADRB1DRD2KDM4EMEN1 | |
| SCHEMBL16066906 | 0.79 | CNR2 (0.42) | ADRB2KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL16067282 | 0.79 | ADRB2 (0.49) | ADRB2ADRB1DRD2DRD3DRD1 | |
| SCHEMBL13868999 | 0.79 | ADRB2 (0.49) | ADRB2ADRB1DRD2DRD3DRD1 | |
| SCHEMBL13868998 | 0.79 | ADRB2 (0.72) | ADRB2ADRB1DRD2DRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641465-B1 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | THERAVANCE INC (US) | 2009-11-04 | — | — | EP | disclosed |