Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845409 | 0.90 | MEN1 (0.42) | TDP1ATMNPSR1MEN1KMT2A | |
| SCHEMBL4713820 | 0.79 | NPSR1 (0.47) | TDP1NPSR1BCHESTK17BSTK17A | |
| SCHEMBL13617409 | 0.78 | TDP1 (0.41) | TDP1ATMNPSR1MEN1KMT2A | |
| SCHEMBL10609690 | 0.78 | TDP1 (0.41) | TDP1ATMNPSR1MEN1KMT2A | |
| SCHEMBL4734573 | 0.77 | STK17B (0.47) | TDP1ATMNPSR1MEN1KMT2A | |
| SCHEMBL3794186 | 0.76 | L3MBTL1 (0.48) | TDP1NPSR1BCHEMAPTSTK17B | |
| SCHEMBL12647368 | 0.76 | TBXAS1 (0.49) | TDP1ATMNPSR1MEN1KMT2A | |
| SCHEMBL6936727 | 0.75 | KLK5 (0.57) | TDP1ATMPOLBMAPTPAX8 | |
| SCHEMBL7452177 | 0.75 | KLK5 (0.57) | TDP1ATMPOLBMAPTPAX8 | |
| SCHEMBL6585454 | 0.75 | TDP1 (0.51) | TDP1ATMNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |